منابع مشابه
Gene therapy in heart failure.
With increasing knowledge of basic molecular mechanisms governing the development of heart failure (HF), the possibility of specifically targeting key pathological players is evolving. Technology allowing for efficient in vivo transduction of myocardial tissue with long-term expression of a transgene enables translation of basic mechanistic knowledge into potential gene therapy approaches. Gene...
متن کاملGene Therapy in Heart Failure
Gene Selection The first challenge in developing gene therapy as a treatment modality is the identification of a gene whose modification will lead to an improvement in the underlying pathophysiology that could translate into improved clinical outcomes. The expression of many hundreds of genes changes in the failing heart; some of these changes are beneficial while others confer negative effects...
متن کاملGene Therapy for Heart Failure
Heart failure is an important public medical problem in the developed countries. Although there are numerous and fascinating medicines given by physicians for the treatment of heart failure, the general 5 year survival rate for advanced heart failure is only about 50%. There are still many theoretical and practical problems to overcome before the application of gene therapy to cardiovascular di...
متن کاملCardiac resynchronization therapy in heart failure.
Cardiac resynchronization therapy (CRT) is a new therapeutic approach for a selected group of patients with symptomatic heart failure (NYHA functional class III-IV) despite optimal medical therapy, due to dilated cardiomyopathy of any etiology (left ventricular ejection fraction < or = 35% and left ventricular end-diastolic diameter > or = 55 mm), who present with electromechanical dyssynchrony...
متن کامل[Cardiac resynchronization therapy for heart failure].
The short-term prognosis of advanced refractory heart failure is extremely poor and closely correlated with progressive left ventricular dysfunction. The identification of the negative effects of conduction delay on cardiac performance, observed in almost 50% of heart failure patients, disclosed a new research field addressing the correction of electrical abnormalities in order to achieve an im...
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ژورنال
عنوان ژورنال: Journal of College of Medical Sciences-Nepal
سال: 2012
ISSN: 2091-0673,2091-0657
DOI: 10.3126/jcmsn.v6i4.6732